Welcome to CFEA (Cell-Free Epigenome Atlas)

cell-free DNA methylation (5mC)

The 5mC browser contains 661 methylomes for healthy controls and patients associated with 10 diseases.

cell-free DNA hydroxymethylation (5hmC)

The 5hmC browser contains 952 hydroxymethylomes for healthy controls and patients associated with 12 diseases.

cell-free nucleosome positioning (NP)

The NP browser contains 56 individuals including healthy controls and patients associated with 17 diseases.

Introduction for CFEA
The cell-free DNA (cfDNA) was shown to be a powerful tool for the noninvasive diagnosis of various diseases and accumulating evidence suggests large-scale epigenetic alterations such as cfDNA methylation (5mC), cfDNA hydroxymethylation (5hmC) and cfDNA nucleosome positioning (NP) can sensitively detect and classify cancers. The CFEA (Cell-Free Epigenome Atlas) data portal is the first database dedicated to human cell-free epigenomes.

What can users do in CFEA
-The users can browse the genome-wide epigenomic data (5mC, 5hmC, and NP) of cell-free DNA from blood (plasma or serum) of healthy individuals and patients with chronic inflammatory and autoimmune diseases, benign and various malignant cancers.
-For researchers interested in the cancer research field, users can easily browse the cfDNA epigenomes at specific stage (such as benign-, early-, late- or metastasis-stage) during cancer development.
-For the interested data of cfDNA or genomic DNA from disease-matched solid tissue, CFEA provide direct visualization and comparison with UCSC genome browser.
-The users can freely download the cell-free epigenomes data processed by standardized pipelines which were suitable for a broad range of technologies.
-The users can process and analyze the public or private cell-free epigenomes data using the CFEA Pipeline.

If you use CFEA in your work, please cite our publication:
Yu F*, Li K*, Li S*, Liu J, Zhang Y, Zhou M, Zhao H, Chen H, Wu N, Liu Z#, Su J#. CFEA: a cell-free epigenome atlas in human diseases. Nucleic acids research 2019, 48(D1): D40-D44.

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