Nucleosome positioning browser
Disease: Different context of cfDNA samples including chronic diseases, benign and malignant cancers, et al.
Sources: Sources of the cell-free DNA.
Detection methods: Users can select an interesting detection method of cfDNA epigenome.
Matched healthy data: Users can decide whether to display cfDNA data from healthy individuals for comparison between disease and health.
Matched gDNA data: Users can decide whether to display the genomic DNA (gDNA) samples from solid tissue with the same disease type of cfDNA samples. To avoid mixing up the concepts of DNA from plasma and DNA from tumor tissue, we referred to somatic DNA from tumor tissues as genomic DNA (gDNA).
Interested gene/region: User can input interested genes (e.g. PTEN) or particular genomic region (e.g. chr10:89596861-89754867), and directly compare epigenetic alterations in/near certain gene or genomic regions by clicking hyperlink in column “UCSC genome browser” of the resulting table or “Send to UCSC genome browser” button in the topleft of resulting table.