Home
Cancer stage browser
CFEA pipelines
Statistics
Tutorial
Download
Contact
Download
Breast cancer
WGBS data
Status
In process
Title
Genome-Wide Cell-free DNA Methylation Analysis Improves the Accuracy of Early-Stage Breast Cancer Diagnosis
Organism
Homo sapiens
Summary
Breast cancer (BC) is the most common cancer in women worldwide. Analysis of circulating tumor DNA (ctDNA) isolated from cell-free DNA (cfDNA) in plasma has emerged as a non-invasive approach for the detection of several malignant tumors. To identify cell-free DNA (cfDNA) methylation markers of malignant and benign breast lesions, whole-genome bisulfite sequencing (WGBS) data from 19 tissue samples (10 benign and 9 malignant) and 203 plasma samples (101 malignant and 102 benign) with BI-RADS category 4 breast lesions were analyzed. Using cfDNA methylation markers, a diagnostic model was developed with better performance than radiology and ultrasound evaluations alone. These findings exemplified the applicability of cfDNA methylation markers in improving the diagnosis of early-stage breast cancer.
Contributor(s)
Deciphering Epigenetic signatures in Tumor and Exploiting ctDNA (DETEct) study
Download
Data files.rar