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Breast cancer

WGBS data

Status In process
Title Genome-Wide Cell-free DNA Methylation Analysis Improves the Accuracy of Early-Stage Breast Cancer Diagnosis
Organism Homo sapiens
Summary Breast cancer (BC) is the most common cancer in women worldwide. Analysis of circulating tumor DNA (ctDNA) isolated from cell-free DNA (cfDNA) in plasma has emerged as a non-invasive approach for the detection of several malignant tumors. To identify cell-free DNA (cfDNA) methylation markers of malignant and benign breast lesions, whole-genome bisulfite sequencing (WGBS) data from 19 tissue samples (10 benign and 9 malignant) and 203 plasma samples (101 malignant and 102 benign) with BI-RADS category 4 breast lesions were analyzed. Using cfDNA methylation markers, a diagnostic model was developed with better performance than radiology and ultrasound evaluations alone. These findings exemplified the applicability of cfDNA methylation markers in improving the diagnosis of early-stage breast cancer.
Contributor(s) Deciphering Epigenetic signatures in Tumor and Exploiting ctDNA (DETEct) study
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